I'm finally able to do some of the things I've wanted to do for ages. The hold up (aside from my inherent laziness) has been hardware and software limitations. I'm finally to the point where I can work on these larger pieces.
This picture was compiled from 13 photos, each adjusted slightly in Lightroom 3, pulled into Photoshop CS5 for the panoramic merging and curve adjustment with a touch of detail work using the Topaz Detail 2 plugin. The result was a 1.4GB PSD file of ~16,000x4000 at 16 bit color depth.